Van Walle I, Gansemans Y, Parren P, Stas Ph, Lasters L. Immunogenicity screening in protein drug development Expert Opinion on Biological Therapy (2007) 7(3):405-18
Fontayne A, Vanhoorelbeke K, Pareyn I, Van Rompaey I, Meiring M, Lamprecht S, Roodt J, Desmet J, Deckmyn H. Rational humanization of the powerful antithrombotic anti-GPIbalpha antibody: 6B4 Journal of thrombosis and haemostasis (2006) 96(5):671-84
Staelens S, Desmet J, Ngo T, Vauterin S, Pareyn I, Barbeaux P, Van Rompaey I, Stassen J, Deckmyn H, Vanhorelbeke K. Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains. Molecular Immunology (2006) 43(8):1243-57
Desmet J, Meersseman G, Boutonnet N, Pletinckx J, De Clercq K, Debulpaep M, Braeckman T, Lasters I. Anchor profiles of HLA-specific peptides: analysis by a novel affinity scoring method and experimental validation. Proteins (2005) 58(1):53-69
Ivo Van Walle, Ignace Lasters, and Lode Wyns. Align-m–a new algorithm for multiple alignment of highly divergent sequences. Bioinformatics (2004), 20(9):1428–35
Van Walle I., Lasters I. & Wyns L. Consistency Matrices: Quantified Structure Alignments
for Sets of Related Proteins Proteins (2003) 51,1–9
Boutonnet N., Janssens W., Boutton C.,Verschelde JL., Heyndrickx L., Beirnaert
E., van der Groen G. & Lasters I. Comparison of Predicted Scaffold-Compatible Sequence
Variation in the Triple-Hairpin Structure of Human Immunodeficiency Virus Type
1 gp41 with Patient Data. J Virol. (2002) 76(15):7595-606
Desmet J, Spriet J & Lasters I. Fast and accurate side-chain topology and energy
refinement (FASTER) as a new method for protein structure optimization. Proteins
(2002) 48(1), 31-43
van den Beucken T., van Neer N., Sablon E., Desmet J., Celis L., Hoogenboom
HR & Hufton SE. Building novel binding ligands to B7.1 and B7.2 based
on human antibody single variable light chain domains. J Mol Biol. (2001) 310(3), 591-601
Boutonnet N., Van Belle D. & Wodak S. Infuence of ligand binding on the conformation of
Ligand of Torpedo
Acetylcholinesterase. Theor. Chem. Acc. (2001) 106, 10-21.
Desmet J., De Maeyer M., Spriet J.& Lasters I. Flexible docking of peptide ligands to proteins. Methods Mol Biol. (2000) 143, 359-76
De Maeyer M., Desmet J.& Lasters I. The dead-end elimination theorem: mathematical aspects,
implementation, optimizations, evaluation, and performance. Methods Mol Biol. (2000) 143, 265-304.
Hufton SE., van Neer N., van den Beucken T., Desmet J., Sablon E.& Hoogenboom
HR.. Development and application of cytotoxic T lymphocyte-associated
antigen 4 as a protein scaffold for the generation of novel binding ligands. FEBS Lett. (2000) 475(3), 225-231.
Boutonnet N., Kajava A. & Rooman M. Structural classification of a
and b supersecondary structure units in proteins. Proteins (1998) 30, 193-212.
Desmet, J., Wilson, I.A., Joniau, M., De Maeyer, M. & Lasters, I. Computation of the binding of fully flexible peptides
to proteins with flexible side-chains. The FASEB J. (1997) 11, 164-172.
De Maeyer, M.., Desmet, J., & Lasters, I. All in one: a highly detailed rotamer library improves
both accuracy and speed in the modeling of side-chains by dead-end elimination. Folding & Design (1997) 2, 53-66.
Lasters, I.., Desmet, J. & De Maeyer, M.. Dead-end based modeling tools to explore the sequence
space that is compatible with a given scaffold. J. Protein Chem. (1997) 16, 449-452.
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Lasters, I.., De Maeyer, M.. & Desmet, J. Enhanced Dead-End Elimination in the search for the
global minimum-energy conformation of a collection of proteins side-chains. Protein Eng. (1995) 8, 815-822.
Boutonnet N., Rooman M. & Wodak S. Automatic analysis of protein conformational changes
of by multiple linkage clustering. J. Mol. Biol. (1995) 253(4), 633-647.
Boutonnet N., Rooman M., Ochagavia M.E., Richelle J. & Wodak S. Optimal protein structure alignments by multiple
linkage clustering: application to distantly related proteins. Protein Eng. (1995) 8(7), 647-662.
Desmet, J., De Maeyer, M.. & Lasters, I.. The 'Dead End Elimination' Theorem as a New Approach
to the side-chain Packing Problem. in 'The Protein Folding Problem and Tertiary Structure Prediction' (1994)
Merz, K. & LeGrand, S. (eds.) Birkhäuser Boston, Inc., pp. 307-337.
Lasters, I.. & Desmet, J. The fuzzy-end elimination theorem: correctly implementing
the side-chain placement algorithm based on the dead-end elimination theorem. Protein Eng. (1993) 6, 717-722.
Desmet, J., De Maeyer, M.., Hazes, B. & Lasters, I.. The Dead End Elimination Theorem and its use in protein
side-chain positioning. Nature (1992) 356, 539-542.
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